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Professor Tianxin Lin from Sun Yat

发布者:admin
日期:2019-07-14 18:30

Professor Tianxin Lin from Sun Yat

Recently,“LNMAT1promoteslymphaticmetastasisofbladdercancerviaCCL2dependentmacrophagerecruitment”,ormicroenvironmentinlymphaticmetastasisandsuggeststhatLNMAT1mayrepresentapotentialtherapeutic,withapproximately429,800newcasesand165,(LN)metasta%%within5years,evenwhenthebladdercanceristreatedwithradicalcystectomy,andLN-metastaticbladderc,thetumormicroenvironmentiscomprisedofdiversenonmalignantstromalcell,whethertargetingtumormicroenvironmentmediatedLN-metastaticcouldbepotentialapproachesfoeslym(lncRNA)associatedwi,lncRNA-BLACAT2canregulatethesecretionofVEGF-CbybladdercancercellsbybindingtoWDR5topromotelymphangiogenesisleadingtolymphaticmetastasis(JClinInvest,2018).However,somepatientswithbladdercancerwhohavelowexpressionofBLACAT2canalsodeveloplymphaticmetastasis,suggestingthatother,,whichisupr,LNMAT1promotes,LNMAT1epigeneticallyactivatesCCL2expressionbyrecruitinghnRNPLtoCCL2promoter,whichleadstoincreasedH3K4,LNMAT1-inducedupregulationofCCL2recruitsmacrophagesintothetumor,microenvironmentinlymphaticmetastasisandsuggestthatLNMAT1mayrepresentapotentialthera:https:///articles/s41467-018-06152-xWrittenby:ChanghaoChenEditedby:theofficeofInternational。

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